皇冠体育注册

美国“南边哈佛”Mazzocchi团队成立肿瘤药敏公司:Known Medicine

宣布日期:2019-08-17  阅读次数:1151

      21世纪,人类安康正在蒙受各类突发疾病和慢性病的侵袭。美国疫情已形成17余万灭亡,比拟恶性肿瘤的情势加倍严重,客岁1年美国癌症灭亡人数超60万。近期,来自具备“南边哈佛”之称的美国维克丛林大学(Wake Forest University生物医学工程学系的Mazzocchi 博士在疫情时期成立了一家公司——Known Medicine,操纵生物医学工程手艺,经由过程体外药敏筛查,赞助每一个肿瘤患者疾速寻觅最好医治决议计划


 一、每一个肿瘤患者都须要最好医治决议计划

Known Medcine :Cancer care has made enormous strides over the years. Despite this proliferation of new treatments, oncologists still rely on certain presumptions to pick the best option for their patients. Known Medicine wants to take away that guesswork. Make no mistake—doctors are the best people to be making such decisions, but they’re “definitely making a best guess,” co-founder and CEO Andrea Mazzocchi said.


      中科皇冠体育:肿瘤大夫常常须要借助生物标记物、病理、临床途径来为患者拟定用药计划,而当患者不明白的生物标记物,或对预期计划不疗效时,大夫和患者城市面对庞大挑衅。20202月成立的Known Medcine公司旨在经由过程成立体外肿瘤模子来赞助大夫“更好的决议计划”,这与中科皇冠体育的奇迹不谋而合,中科皇冠体育承袭我国西医“同病异治、异病同治”的理念,接纳“老药新用”的手腕,经由过程PDCPDOPDX等肿瘤模子,赞助每一个肿瘤患者精准选药,使得临床决议计划不受生物标记物和特定驱动基因的限定,让每一个肿瘤患者都能用上合适自身的疗法,这对肿瘤的医治来讲是很有须要的。

 

二、体外构建肿瘤模子是关头

      Known Medcine :Here’s how it works: Known Medicine receives a tumor sample from a hospital and breaks it down into several mini-tumors in its lab. It then doses each model with different cancer drugs and drug combinations to see what works best for each patient.

      “We want to know what the longer-term effects of these drugs are, beyond just the five-day assay we run,” Skelly said, adding that the company could use machine learning to find cells that are pre-apoptotic—on their way to death—that would show up as alive in its test, but would respond to treatment over time.



      中科皇冠体育:今朝肿瘤用药展望模子代表性的有类器官、PDXmini-tumor、原代细胞等,这些手艺转向临床须要同时具备以下几个因素:1)疾速,肿瘤大夫在患者病理确诊后或复发后须要第临时候拟定医治计划,这就请求操纵模子撑持医治决议计划的时候越短越好,今朝临床可领受的周期为1-2周;2)通量高,所谓通量即在单个周期内检测的药物数目,只要检测的药物充足多,能力应答肿瘤庞杂多变的特征,赞助患者实时锁定可挑选的有用计划;3)胜利率高,肿瘤体外建模须要获得患者的肿瘤样本,因为肿瘤患者停止临床取样的机遇无限,咱们以为只要胜利率高于90%时才合适临床推行;4)可丈量,除须要可供评估体外药敏的目标,如药物浓度、细胞凋亡、肿瘤巨细等,还须要模子自身在评估药物时具备不变性、同步性、可反复性。


三、精准用药战略有讲求

      Known MedicineKnown Medicine’s approach focuses on the FDA-approved standard of care for each specific cancer. It could be particularly helpful in suggesting the off-label use of different chemotherapies that “are not so obvious to find,” Mazzocchi said. The company works closely with oncologists at Wake Forest, to stay on the “cutting edge” of cancer treatment and make sure it’s not missing any possible options.



      “In the longer term, that will likely also involve partnerships and discovering new treatments for patients. That’s one of our long-term visions,” Skelly said. “But any way we can make sure patients are treated in the best possible way—that is what we’re chasing after, first and foremost.”



      中科皇冠体育:Known Medicine公司起首对准了FDA保举的肿瘤医治药物和计划,赞助患者在现有药物里作出最好挑选,而后再操纵后续培育系统挑选新药和新的组合计划。中科皇冠体育颠末5年多的临床理论发明,对初期或初诊的肿瘤患者,可以或许先停止10-20个临床经常使用药物的检测,此时常常是抗癌最好医治机会,首要赞助患者进步初次医治胜利率,提早复发时候窗或尽能够防止复发;对中早期或复举事治型肿瘤患者,接纳大范围药物挑选的战略,一次检测上百个药物,来进步有用药物挖掘胜利率,包含靶向药物、中药单体、临床实验药物、组合计划等。


四、将来可期

      Known MedicineMoving forward, the company hopes to develop a testing kit for research use, and then one for clinical use, Mazzocchi said. The goal is to put its product in every hospital or cancer clinic, not just to help patients, but also to collect data to eventually be used in drug discovery.

“In the future, we will be able to look at a picture of a [mini-tumor] that’s been treated with a drug and tell you whether that treatment is working or not,” Skelly said.

      中科皇冠体育:肿瘤建模和个别化医治还将鞭策新药精准研发、医疗大数据、肿瘤医治形式的成长,或许多少年前任何一个肿瘤患者都可以或许在很短的时候内获得一套合适自身的医治形式,能够是几小时,也能够只须要几分钟...

      跟着国际外处置以肿瘤构造成长差别模子来停止药物挑选的机构不时增添,信任肿瘤精准医治将产生质的奔腾,这也是生物医药行业在数据信息时期的成长趋向

      中科皇冠体育初创HDS肿瘤精准用药检测手艺系统,具备疾速、精准、通量高档特色,正在扶植中国可再生原代细胞性命银行,接待征询协作!